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Rigor mortis : how sloppy science creates worthless cures, crushes hope, and wastes billions / by Harris, Richard F.;
Includes bibliographical references (pages 239-264) and index.Begley's bombshell -- It's hard even on the good days -- A bucket of cold water -- Misled by mice -- Trusting the untrustworthy -- Jumping to conclusions -- Show your work -- A broken culture -- The challenge of precision medicine -- Inventing a discipline."Biomedical science--the research that underlies our treatments and cures--is in deep crisis. Every year, American taxpayers spend more than $30 billion funding it. About half of that work, by some estimates, is wrong. As award-winning science journalist Richard Harris reveals in Rigor Mortis, this is not simply the result of trial and error, which is an essential part of the scientific process. The economic imperative for researchers to get and keep jobs and funding encourages dubious behavior, from poor experimental design to sloppy statistics and shoddy analysis. Add to that a bunch of mislabeled cell lines and mishandled ingredients, and what seems like a potential cure becomes an unreliable mess. Some 900 breast-cancer studies were conducted with cells that weren't breast-cancer cells at all, new "treatments" for ALS developed in rodent models failed when retested properly in mice, and only 1.2 percent of early papers in genomics stand the test of time. These problems aren't the exception. They are commonplace. This crisis of reproducibility--when studies done in one lab fail when another tries to reproduce their results--isn't just holding back scientific progress--it's a devastating blow for patients everywhere who are hoping that medical science will give them longer, healthier lives. Rigor Mortis explores these urgent issues through vivid anecdotes, personal stories, and interviews with the nation's top biomedical researchers, some of whom are now struggling to set things right. An unsparing investigation that lays bare the dysfunctions in our research system, this book represents the first step toward fixing it."--Jacket.
Subjects: Medicine; Medical ethics.;
Available copies: 1 / Total copies: 1
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An odyssey with animals : a veterinarian's reflections on the animal rights & welfare debate / by Morrison, Adrian R.;
Includes bibliographical references and index.Searching for the boundary between animals and humans -- Victims -- "Doing" science -- Biomedical research and its animals -- Fudging the data -- The history of modern animal-rights activism -- Exploring the nature of animals -- Justifying other uses of animals -- The philosophers.The relationship between animals and humans is more complex today than ever before. In addition to the animals that have served as household pets, and the farm animals that have provided labor and food, countless monkeys, rabbits, rats, and cats have enabled modern scientists to treat and cure humanity's most devastating illnesses. This aspect of animal-human interaction has engendered a bitter enmity between animal rights activists and the biomedical researchers whose work depends on the use (and oftentimes the killing) of laboratory animals. In this work, the author, a veterinarian and sleep researcher argues that humane animal use in biomedical research is an indispensable tool of medical science, and that efforts to halt such use constitute a grave threat to human health and wellbeing. The target of repeated acts of intimidation by anonymous animal rights activists because of his own research, he is himself an animal advocate, and this volume is the culmination of his years spent negotiating the treacherous divide between a legitimate concern for animals and the importance of biomedical research. Drawing on the disciplines of philosophy, history, biology, and animal behavior, he crafts a multi-faceted argument in favor of using animals humanely in research, the center of which is his staunch belief that human interests must be the primary concern of science and society. Along the way, he delves into other human uses of animals in domains such as agriculture, hunting, and education, examining each use along with its philosophical, moral, and ecological implications. The result is a discussion of a charged subject, of the past and present of animals' relationships with humans, and how and why we should be able to use them as we do.
Subjects: Medical sciences; Biology; Laboratory animals.; Animal experimentation.; Animal welfare; Animal Experimentation; Animal Rights.; Animals, Laboratory.; Biomedical Research; Ethics, Research.;
© c2009., Oxford University Press,
Available copies: 1 / Total copies: 1
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The Rowman & Littlefield handbook of bioethics / by Di Nucci, Ezio,editor.; Lee, Ji-Young(Researcher in Bioethics),editor.; Wagner, Isaac A.,editor.;
This bioethics handbook offers concise, up-to-date, and easy to read chapters on a broad range of bioethical topics in the following categories: foundational concepts, theory and method, healthcare ethics, research ethics, public health, technology, and the environment. The volume provides a snapshot of current bioethics, taking into account current affairs and emerging new topics. Each chapter acknowledges and critically breaks down the historical developments of the subject and the most authoritative existing literature on respective topics, providing accessible and up-to-date philosophical analysis. As such, the chapters are designed to be attractive as primary or supplementary teaching material for university classes of the philosophical or bioethical variety, with clear demarcations and indicators for key terms, ideas, and arguments that should also facilitate productive note-taking and points for critical discussion for students. The handbook also serves as a one-stop starting resource for multi- and interdisciplinary researchers and practitioners who engage with bioethics in their work.Description based on print version record.Electronic reproduction. Ann Arbor, MI : ProQuest, 2018. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
Subjects: Electronic books.; Bioethics; Medical ethics.; Research;
On-line resources: https://ebookcentral.proquest.com/lib/kirtland-ebooks/detail.action?docID=7133013 -- Available online. Click here to access.;
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Sacred cells? : why Christians should support stem cell research / by Peters, Ted,1941-; Lebacqz, Karen,1945-; Bennett, Gaymon,1972-;
Includes bibliographical references and index.The ethical prehistory of stem cells -- From science to ethics in a flash -- Working within the research standards framework -- Three contending frameworks for stem cell ethics -- The embryo protection framework -- The human protection framework -- The future wholeness framework -- Ethical smoke and mirrors in Washington -- The hidden theology behind the international debates -- The Vatican's strong stand -- The Vatican and embryology -- The Vatican argument in a cracked nutshell -- Leon Kass, protector of human nature -- Jewish and Muslim bioethics -- The terror of the chimera -- Justice and the patenting controversy -- The spiritual soul and human dignity -- The ethics of the ethicists -- Theologians say "yes" to regenerative medicine.Sacred Cells? takes readers through the twists and turns of stem cell development, providing a brief history of the science and an overview of the competing ethical frameworks people use in approaching the heated debate. Each new scientific advance, from the cloning of Dolly the sheep to the use of engineered cells in humans, had to be carefully considered before proceeding. Rejecting the widely held belief that the ethics of stem cell research turn on the moral status of the embryo, the authors carefully weigh a diversity of ethical problems. Ultimately, they embrace stem cell research and the prospect of increased health and well being it offers. --from publisher description.
Subjects: Stem cells; Stem Cells.; Christianity.; Embryo Research;
© c2008., Rowman & Littlefield Publishers,
Available copies: 1 / Total copies: 1
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The stem cell divide : the facts, the fiction, and the fear driving the greatest scientific, political, and religious debate of our time / by Bellomo, Michael.;
Includes bibliographical references (p. 233-241) and index.Discovery of the stem cell's unique abilities -- Morning on the devil's highway -- Head of the hydra -- The furnace of creation -- The ugliest thing in medicine -- The starter culture -- The race to harness the power of life -- California dreaming -- Investing in hope and hype -- From Roe to Dickey -- Division on the hill -- Stem cell superpowers -- The rise and fall of South Korea's cloning king -- Stem cell cures and curses -- Therapeutic cloning and regenerative medicine -- Resolving the debate: adult vs. embryonic stem cells -- Germ of an idea -- Needles and haystacks -- Banking on cord blood -- So close and yet so far -- A future built on the smallest piece of life -- The mitochondrial barrier -- Cautionary tales: the coming stem cell decade -- Epilogue: the coming stem cell century.
Subjects: Stem cells; Embryonic stem cells;
© c2006., American Management Association,
Available copies: 1 / Total copies: 1
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Stem cells, human embryos and ethics : interdisciplinary perspectives / by Ãstnor, Lars,1939-;
Includes bibliographical references and index.The moral status of human embryos with special regard to stem cell research and therapy / Ãyvind Baune, Ole Johan Borge, Steinar Funderud, Dagfinn Føllesdal, Gunnar Heiene, and Lars Ãstnor -- Part I Biological and Medical Perspectives -- Stem cells: sources and clinical applications / Steinar Funderud -- Alternative means to obtain pluripotent stem cells / Ole Johan Borge -- Neurogenesis and potential use of stem cells from adult human brain / Havard Ãlstørn, Morten C. Moe. Mercy Varghese, and Iver A. Langmoen -- Can we use human embryonic stem cells to treat brain and spinal cord injury and disease? / Joel C. Glover -- Stem cells, embryos and ethics: is there a way forward? / William B. Hurlbut -- Part II Social and Political Perspectives -- An intercultural perspective on human embryonic stem cell research / LeRoy Walters -- Human embryo research: the European perspective / Egbert Schroten -- Stem cells, pluralism and moral empathy / Theo A. Boer -- Part III Philosophical Perspectives -- The potentiality argument and stem cell research / Dagfinn Føllesdal -- Can the distinction between the moral and the descriptive support a full moral standing of an embryo? / Ãyvind Baune -- The beginning of individual human life / Anthony Kenny -- Embryonic stem cell research - arguments of the ethical debate in Germany / Ludger Honnefelder -- The question of human cloning in the context of the stem cell debate / Otfried HoÌffe -- Part IV Theological Perspectives -- Stem cells from human embryos for research? The theological discussion within Christianity / Lars Ãstnor -- Theological arguments in the human stem cell debate: a critical evaluation / Gunnar Heiene -- Human embryos and embryonic stem cells - ethical aspects / Monika Bobbert.
Subjects: Stem cells; Human embryo;
© c2008., Springer,
Available copies: 1 / Total copies: 1
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The Baltimore case : a trial of politics, science, and character. by Kevles, Daniel Jo.;
Subjects: Fraud in science.; Cellular immunity;
© 2000., W.W. Norton,
Available copies: 1 / Total copies: 1
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Stop plagiarism : a guide to understanding and prevention / by Cvetkovic, Vibiana Bowman,1953-; Anderson, Katie Elson,1973-;
Includes bibliographical references and index.Designed to be of use to all levels of educators working with students, from high school to post-graduate, this book addresses the problems and concerns facing librarians and educators involved in the process of teaching academic honesty. Many of the original authors from The Plagiarism Plague have returned with new essays along with new voices, a majority of whom represent the next generation of librarianship, the Web 2.0 professional. This book contains background material, web resources, a collection of sample exercises, and an interactive CD that provides tools an educator can use to stop plagiarism. One of three videos on the CD features an animated interactive quiz that helps student understand when they must include a citation. The authors have also established an anti plagiarism wiki where readers are encouraged to participate in the on going conversation on plagiarism. This is a source for anyone who wants to understand why students knowingly or unknowingly plagiarize, who needs materials for teaching academic integrity, and who will benefit from a current resource guide to tools for actively detecting plagiarism. -- From publisher.Teaching intellectual honesty in a parodied world / Katie Elson Anderson and Vibiana Bowman Cvetkovic -- The onus of originality : creativity and accomplishment in a digital and competitive age / Laura B. Spencer -- The dark side of the Web : where to go to buy a paper / Nick Cvetkovic -- The academy versus plagiarism : rearranging the deck chairs on the Titanic or the stand at Thermopylae / Vibiana Bowman Cvetkovic and Luis F. Rodriguez -- An undergraduate's perspective / Sarah F. Brookover -- Creating a tutorial : background, theory, and practical application / Vibiana Bowman Cvetkovic and John B. Gibson -- The first-year college experience / Gillian A. Newton and Jeffrey J. Teichmann -- Plagiarism : university reaction and subsequent action / Dolores Pfeuffer-Scherer -- Plagiarism and the nontraditional student : challenges and perspectives / Dawn Amsberry -- Plagiarism : the legal landscape / Robert Berry -- Professional organizations' recommendations regarding intellectual honesty / Frances Kaufmann and Julie Still -- Inoculating against plagiarism : resources for teaching and learning / Leslie Murtha -- Write it, then cite it : guiding students toward reliable techniques and resources for effective scholarly writing / Robert J. Lackie -- Plagiarism : an annotated bibliography / Patience L. Simmonds.
Subjects: Plagiarism.; Cheating (Education); Internet research; Plagiaat; Wetenschapsbeoefening;
© c2010., Neal-Schuman Publishers,
Available copies: 1 / Total copies: 1
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The immortal life of Henrietta Lacks [sound recording] / by Skloot, Rebecca,1972-; Campbell, Cassandra.nrt; Turpin, Bahni.nrt;
Reading by Cassandra Campbell with Bahni Turpin of the 2009 book.Documents the story of how scientists took cells from an unsuspecting descendant of freed slaves and created a human cell line that has been kept alive indefinitely, enabling discoveries in such areas as cancer research, in vitro fertilization, and gene mapping.
Subjects: Audiobooks.; Compact discs.; Lacks, Henrietta, 1920-1951; Cancer; African American women; Human experimentation in medicine; HeLa cells.; Cancer; Cell culture.; Medical ethics.;
© p2010., Random House Audio,
Available copies: 1 / Total copies: 1
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The immortal life of Henrietta Lacks / by Skloot, Rebecca,1972-;
Includes bibliographical references (pages 346-366) and index.Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor black tobacco farmer whose cells--taken without her knowledge in 1951--became one of the most important tools in medicine, vital for developing the polio vaccine, cloning, gene mapping, and more. Henrietta's cells have been bought and sold by the billions, yet she remains virtually unknown, and her family can't afford health insurance. This phenomenal New York Times bestseller tells a riveting story of the collision between ethics, race, and medicine; of scientific discovery and faith healing; and of a daughter consumed with questions about the mother she never knew.
Subjects: Lacks, Henrietta, 1920-1951; Cancer; African American women; Human experimentation in medicine; HeLa cells.; Cancer; Cell culture.; Medical ethics.;
Available copies: 1 / Total copies: 1
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Results 1 to 10 of 164 |