Mutation : the history of an idea from Darwin to genomics
Record details
- ISBN: 1936113309
- ISBN: 9781936113309
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Physical Description:
viii, 163 p. : ill. ; 24 cm.
print - Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2011.
Content descriptions
Bibliography, etc. Note: | Includes bibliographical references and index. |
Formatted Contents Note: | A brief overview of the concept of mutation -- Ideas of mutation before there was a Mendelian basis for genetics -- Cytological and Mendelian aspects of mutation -- The fly lab redefines mutation -- Radiation and the analysis of mutation by mutagenesis -- Using biochemical approaches to study mutation -- Mutation in relation to gene structure -- Mutation in relation to evolution -- Mutation in relation to genetic engineering -- Mutation in relation to society -- Mutation in relation to history and philosophy of science. |
Search for related items by subject
Subject: | Mutation (Biology) Mutation (Biology) Research Genomics Mutation Genetics history History, 19th Century History, 20th Century |
Available copies
- 1 of 1 copy available at Kirtland Community College.
Holds
- 0 current holds with 1 total copy.
Show Only Available Copies
Location | Call Number / Copy Notes | Barcode | Shelving Location | Status | Due Date |
---|---|---|---|---|---|
Kirtland Community College Library | QH 460 .C37 2011 | 30542034 | General Collection | Available | - |
Mutation: the History of an Idea from Darwin to Genomics
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Summary
Mutation: the History of an Idea from Darwin to Genomics
Today, most scientists regard the term "mutation" as a description of a change in an individual gene, and more precisely as some minute alteration of the DNA of that gene, especially a nucleotide substitution. But the idea of mutation has changed considerably from the pre-Mendelian concepts of Darwin's generation, who viewed "fluctuating variations" as the raw material on which evolution acted, to today's up-to-the-minute genomic context of mutation. Mutation: The History of an Idea from Darwin to Genomics explores six generations of mutation research, providing the background--the people and the ideas--for this biological journey. After exploring Darwin's and Francis Galton's concepts of mutation, Carlson shows how the 1900 rediscovery of Gregor Mendel's experiments let to a discontinuous model of evolution by mutation and how cytological investigations led to the chromosome theory of heredity of classical genetics in which there was random mutation in genes. Carlson details how Mendelian and biometric approaches to heredity and evolution were closely tied and how induction of mutations by radiation and chemical mutagens led to biochemical investigations of gene action, shifting attention to the chemistry of the gene. The interpretation of the gene as DNA and the deciphering of the genetic code then gave rise to molecular interpretations of mutation, views that also impacted evolutionary biology, population genetics, commercial development of plants and animals, and human genetics. This book shows how generational definitions or assessments of mutation have responded to the technologies added to science and the experiments that abounded with the inquiries of each successive generation. These observations are combined with an exploration of how the nonscientific public has shifted its understanding and concern about mutations over the past 150 or more years. Carlson's historical approach in this book--examining the evolution of a concept--reveals the way science works, incrementally by small steps of additions and replacements rather than by dramatic, and rare, paradigm shifts.